[Effect of cimetidine on experimental atherogenesis in rabbits]

It was shown that cimetidine (10 mg/kg, 12 weeks) reduces the frequency and the degree of affection of rabbit's aortas during experimental cholesterol atherosclerosis. The protective effect of cimetidine on the liver where the contents of lipids, especially cholesterol esters reduced considerably, was noted. The nature of the fatty dystrophy changes from the large-drop to the small-drop one which should be considered as a favourable phenomenon. The anti-atherogenic and hepatoprotective effects of cimetidine can be explained by slowing-down of lipoperoxidation processes which is proved in respect of blood and aorta walls.