[Immunodepressive effect of transcerebral lasers]

Area of Science:

• Immunology
• Endocrinology
• Laser Physics

Background:

• Endocrine regulation plays a crucial role in modulating immune responses.
• The endogenous opioid system is implicated in immune modulation.
• Infrared laser radiation's effects on these systems require further investigation.

Purpose of the Study:

• To investigate the impact of infrared laser radiation on the endocrine regulation of immunogenesis.
• To examine the influence of laser radiation on the endogenous opioid system.
• To understand the relationship between laser-induced immunodepression and hormonal changes.

Main Methods:

• Experiments were conducted on rabbits.
• Transcranial infrared laser radiation was applied.
• Primary immune response (PIR) was induced using a thymus-dependent antigen (sheep red blood cells).
• Blood plasma opioid concentration and adrenal cortex glucocorticoid activity were measured.

Main Results:

• Infrared laser radiation suppressed the primary immune response (PIR) in all tested rabbits.
• Impulse laser radiation resulted in more pronounced immunodepression.
• Immunodepression was associated with increased glucocorticoid activity of the adrenal cortex.
• A significant decrease in opioid concentration in blood plasma was observed following impulse radiation (0.08 Joules).
• No significant changes in thyroid hormones were detected.

Conclusions:

• Infrared laser radiation, particularly impulse exposure, exerts an immunosuppressive effect in rabbits.
• Laser-induced immunodepression is linked to heightened glucocorticoid activity.
• The observed decrease in plasma opioids may result from rapid exhaustion of opioid synthesis following laser stimulation.
• These findings highlight the complex interplay between laser radiation, endocrine function, and the immune system.