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Impairment of mitochondrial oxidative phosphorylation in the brain of aged mice
M L Ferrándiz1, M Martínez, E De Juan
1Instituto de Neurociencias, Facultad de Medicina, Universidad de Alicante, Spain.
Brain Research
|May 2, 1994
Abstract:
To elucidate the role of mitochondrial oxidative phosphorylation in neuronal aging, we have studied the activity of the respiratory complexes in the brain of young, adult and old mice. In synaptic mitochondria, we found a significant decrease in complexes IV (29%, P < 0.001) and V (21%, P < 0.01) in old as compared with adult mice. Nonsynaptic mitochondria also showed a senescent decrease in complexes I (15%, P < 0.01), II + III (34%, P < 0.01) and IV (17%, P < 0.01) activities. These findings suggest a dysfunction in mitochondrial oxidative phosphorylation in brain aging.