Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stelazine-induced pigmentation

C Buckley1, V Thomas, J Lewin

  • 1Department of Dermatology, Royal Free Hospital, Hampstead, London, UK.

Clinical and Experimental Dermatology
|March 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endothelial Cell Organization Drives Distinct Agonist-Specific Ca<sup>2+</sup> Dynamics in Arteries and Veins.

Acta physiologica (Oxford, England)·2025
Same author

Unseen pathogen pathways: the impact of high-touch surfaces in public spaces.

Perspectives in public health·2025
Same author

Inside-Out IP<sub>3</sub>-Mediated G Protein-Coupled Receptor Activation Drives Intercellular Ca<sup>2+</sup> Signaling in the Vascular Endothelium.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2025
Same author

Simulation of management practices to reduce nitrogen losses to water and air on well-drained grass-based dairy farms in derogation.

Journal of dairy science·2025
Same author

Effects of grazing platform stocking rate on productivity and profitability of pasture-based dairying in a fragmented farm scenario.

Journal of dairy science·2023
Same author

Genome-based epidemiology and antimicrobial resistance of Neisseria gonorrhoeae in Spain: A prospective multicentre study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2023
Same journal

Real-World Outcomes of Stapokibart-Based Combination Therapy for Bullous Pemphigoid: A Single-Center Retrospective Cohort.

Clinical and experimental dermatology·2026
Same journal

A second case of recessive mosaicism in ABCA12 causing a congenital unilateral epidermal nevus.

Clinical and experimental dermatology·2026
Same journal

Dermatopathology.

Clinical and experimental dermatology·2026
Same journal

Persistent Bilateral Palmar Hyperkeratotic Papules in an Adolescent Male.

Clinical and experimental dermatology·2026
Same journal

Shuddering Attacks in an Infant Treated with Atenolol for Infantile Hemangioma: A Previously Unreported Adverse Effect.

Clinical and experimental dermatology·2026
Same journal

Male genital fixed drug eruption: a systematic review.

Clinical and experimental dermatology·2026
See all related articles

A patient developed blue-grey skin pigmentation from long-term, low-dose Stelazine treatment. This rare side effect, oculocutaneous melanosis, affects sun-exposed areas due to phenothiazine use.

Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Oculocutaneous melanosis is a known side effect of prolonged phenothiazine treatment.
  • This condition causes violaceous, blue-grey, or slate-grey discoloration of sun-exposed skin.
  • These characteristic changes are infrequently observed in contemporary clinical practice.

Observation:

  • A West Indian patient developed abnormal blue-grey skin pigmentation.
  • The pigmentation occurred on exposed areas of the skin.
  • The patient had been treated with a low dose of Stelazine for five years.

Findings:

  • The case demonstrates the occurrence of oculocutaneous melanosis.
  • Pigmentation developed despite a low dosage of Stelazine.
  • The duration of treatment (5 years) was a contributing factor.

Related Experiment Videos

Implications:

  • This case underscores the importance of monitoring for rare side effects like oculocutaneous melanosis, even with low-dose phenothiazine therapy.
  • Awareness of this side effect is crucial for clinicians managing patients on long-term phenothiazine treatment.
  • Sun protection measures may be important for patients on these medications.