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Clinicopathological study of poststreptococcal glomerulonephritis in the elderly
1Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Clinical Nephrology
|May 1, 1994
Summary
Elderly patients with poststreptococcal glomerulonephritis (PSGN) show higher rates of kidney impairment and hypertension. However, their short-term prognosis remains favorable, with no deaths or persistent renal failure observed.
Area of Science:
- Nephrology
- Geriatrics
- Immunology
Background:
- Poststreptococcal glomerulonephritis (PSGN) is a kidney disease typically affecting younger individuals.
- Clinical features and outcomes of PSGN in elderly populations are not well-characterized.
Purpose of the Study:
- To characterize the clinical features and short-term prognosis of PSGN in elderly patients compared to younger age groups.
Main Methods:
- Retrospective analysis of 31 histologically and immunologically confirmed PSGN patients.
- Patients were categorized into three age groups: elderly (≥55 years), middle-aged (40-54 years), and younger (20-39 years).
- Clinical data including renal function, blood pressure, and laboratory markers were compared across groups.
Main Results:
- Elderly PSGN patients exhibited a higher incidence of renal functional impairment (serum creatinine > 2.0 mg/dl) and hypertension upon admission (86%) compared to younger patients (6%).
- Despite initial impairment, renal function improved in elderly patients within the follow-up period (178.9 ± 150.7 days).
- Hypertension persisted in 43% of elderly patients at discharge; however, no deaths or persistent renal failure occurred in this group.
Conclusions:
- Elderly patients with PSGN present with increased renal functional impairment and hypertension on admission.
- Despite these initial challenges, the short-term prognosis for elderly PSGN patients appears favorable.
- Age does not significantly impact immunological markers or histological findings in PSGN.