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Effect of intracerebral serotonin administration on pituitary-thyroid function
Endocrinologia Experimentalis
|June 1, 1975
Summary
Serotonin administration significantly reduced thyroid function by lowering thyrotrophic hormone releasing hormone (TRH) secretion in the hypothalamus. This indicates serotonin inhibits the hypothalamo-pituitary-thyroid axis.
Area of Science:
- Neuroendocrinology
- Thyroid physiology
Background:
- The hypothalamo-pituitary-thyroid (HPT) axis regulates thyroid hormone production.
- Serotonin is a neurotransmitter with widespread effects on physiological systems.
Purpose of the Study:
- To investigate the effect of serotonin on thyroid function.
- To determine if serotonin influences the hypothalamo-pituitary-thyroid axis.
Main Methods:
- Intrahypothalamic implantation of serotonin-creatine sulphate.
- Intraventricular injection of serotonin-creatine sulphate.
- Histological evaluation of thyroid gland activity and measurement of thyroid/serum 131-I ratio, pituitary thyrotropic hormone (TSH), and hypothalamic thyrotropin-releasing hormone (TRH).
Main Results:
- Serotonin treatment significantly decreased thyroid/serum 131-I ratio, thyroid gland activity, pituitary TSH content, and hypothalamic TRH concentration.
- Control groups (creatine-sulphate) showed minimal changes, suggesting a specific effect of serotonin.
Conclusions:
- Serotonin inhibits the functional activity of the hypothalamo-pituitary-thyroid system.
- The mechanism involves the inhibition of TRH secretion from the hypothalamus.