Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Modulation of NMDA receptor function: implications for vertebrate neural development

A J Scheetz1, M Constantine-Paton

  • 1Department of Biology, Yale University, New Haven, Connecticut 06511.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|July 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Central projections of anuran optic nerves penetrating hindbrain or spinal cord regions of the neural tube.

Brain research·2011
Same author

Developmental depression of glutamate neurotransmission by chronic low-level activation of NMDA receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001
Same author

Chronic NMDA receptor blockade from birth increases the sprouting capacity of ipsilateral retinocollicular axons without disrupting their early segregation.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001
Same author

Activity-dependent induction of tonic calcineurin activity mediates a rapid developmental downregulation of NMDA receptor currents.

Neuron·2000
Same author

The plastic brain.

Neurobiology of disease·2000
Same author

Chronic NMDA exposure accelerates development of GABAergic inhibition in the superior colliculus.

Journal of neurophysiology·2000

The N-methyl-D-aspartate (NMDA) receptor regulates synapse stabilization in the developing brain. Activity-dependent changes in NMDA receptor function may offer new strategies for brain repair after injury.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Synaptic Plasticity

Background:

  • The N-methyl-D-aspartate (NMDA) receptor is crucial for synaptic plasticity and development.
  • NMDA receptor function is implicated in synapse elimination and sensory map formation.
  • Elevated NMDA receptor activity is observed during critical periods of synaptic rearrangement.

Purpose of the Study:

  • To propose a corollary to the NMDA receptor hypothesis for activity-dependent synapse stabilization.
  • To explore the role of NMDA receptor subunit composition in synaptic plasticity.
  • To investigate the potential of NMDA receptor regulation for adult brain repair.

Main Methods:

  • This review synthesizes existing research on NMDA receptor function during brain development.

Related Experiment Videos

  • It discusses the proposed feedback system linking synaptic activity to NMDA receptor subunit changes.
  • The review examines the implications of developmental NMDA receptor expression for adult plasticity.

    • Main Results:

    • Increased neuronal activity leads to greater postsynaptic Ca2+ influx via NMDA receptors.
    • This Ca2+ influx may trigger a feedback mechanism altering NMDA receptor subunit composition.
    • Altered NMDA receptor effectiveness correlates with changes in neuronal activity.

    Conclusions:

    • NMDA receptor function is dynamically regulated by neuronal activity during development.
    • Developmental NMDA receptor subunit combinations may facilitate synaptic rearrangement in the adult brain.
    • Understanding NMDA receptor regulation offers potential therapeutic avenues for brain damage.