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[Crohn disease caused by antibiotics? A medical hypothesis based on epidemiologic data]
1Medizinischen Klinik, Universität Erlangen-Nürnberg, Schlüsselfeld.
Abstract:
The increasing incidence of Crohn's disease over the last 50 years has paralleled the growing use of antibiotics in human and veterinary medicine. Administered at inadequate doses, antibiotics can induce in bacteria a capability for producing toxins. Statistical considerations also indicate that prior antibiotic treatment promotes the development of Crohn's disease. It seems logical to assume that, in persons with a relevant genetic predisposition, this disease is caused by intestinal bacteria, the biological (not morphological) properties of which have been modified by antibiotics.
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