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Related Experiment Videos

A computer-controlled system for post-stimulus time histogram and wind-up studies

D Budai1

  • 1Department of Veterinary Pathobiology, University of Minnesota, College of Veterinary Medicine, St. Paul 55108.

Journal of Neuroscience Methods
|March 1, 1994
PubMed
Summary

This study presents a LabVIEW virtual instrument (VI) system for analyzing spinal cord neural activity evoked by peripheral nerve stimulation. The system enables on-line and off-line analysis of neuronal responses, including wind-up phenomena.

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Computational Neuroscience

Background:

  • Electrophysiological recordings from the spinal cord are crucial for understanding neural processing.
  • Analyzing neuronal responses to peripheral nerve stimulation requires specialized data acquisition and analysis systems.

Purpose of the Study:

  • To describe a LabVIEW virtual instrument (VI)-based system for stimulating peripheral sensory fibers.
  • To enable analysis and storage of electrophysiological data from the spinal cord.
  • To facilitate on-line and off-line analysis of neuronal firing patterns and wind-up.

Main Methods:

  • Utilized a multifunction data acquisition (input/output; I/O) board and custom LabVIEW VIs.
  • Stimulated dorsal horn neurons with C-fiber strength electrical stimuli.

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  • Recorded extracellular action potentials using a carbon-fiber microelectrode.
  • Computed post-stimulus time histograms (PSTH) and analyzed response latency.

    • Main Results:

    • The system successfully recorded and analyzed neuronal responses to A- and C-fiber inputs.
    • Demonstrated on-line computation of PSTH for visualizing neuronal firing.
    • Quantified wind-up phenomena, showing potentiation of C-fiber evoked responses.
    • Showed NMDA increased wind-up, while MK-801 decreased it.

    Conclusions:

    • The developed LabVIEW VI system is effective for combined PSTH and wind-up analysis.
    • The system supports both on-line data processing and off-line examination of recorded data.
    • This tool aids in studying spinal cord neuronal plasticity and response to sensory input.