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Related Experiment Videos

Phenytoin for motion sickness: clinical evaluation

G W Knox1, D Woodard, W Chelen

  • 1Baylor College of Medicine, Houston, Texas.

The Laryngoscope
|August 1, 1994
PubMed
Summary

Phenytoin effectively prevents motion sickness at blood levels above 9 micrograms/mL. This anticonvulsant may work by affecting both central nervous system and peripheral vestibular functions.

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Area of Science:

  • Neuroscience
  • Vestibular Science
  • Pharmacology

Background:

  • Phenytoin (an anticonvulsant) has demonstrated protective effects against motion sickness.
  • Further investigation is needed to confirm its efficacy and understand its mechanism.

Purpose of the Study:

  • To further evaluate phenytoin's effectiveness in preventing motion sickness.
  • To explore the underlying mechanisms of phenytoin's anti-motion sickness action.

Main Methods:

  • Participants received phenytoin or placebo.
  • Evaluations included electronystagmography, off-vertical rotation, sea travel, and parabolic flight.
  • Blood phenytoin levels were monitored.

Main Results:

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  • A blood level of at least 9 micrograms/mL was associated with protection against motion sickness.
  • Phenytoin administration led to significant reductions in vestibuloocular reflex gain.
  • Minimal side effects were observed within the therapeutic range (9-15 micrograms/mL).

    • Conclusions:

    • Phenytoin is a viable option for motion sickness prevention.
    • Its efficacy may stem from combined central nervous system and peripheral vestibular system effects.