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Expression of astroglial nerve growth factor in damaged brain
1Department of Neurophysiology, Nencki Institute of Experimental Biology, Warsaw, Poland.
Acta Neurobiologiae Experimentalis
|January 1, 1994
Abstract:
This article provides an overview of different brain insults leading to induction of astroglial NGF expression. It discusses mechanisms of induction of astroglial NGF in a damaged brain and a possible role of its expression in pathophysiology of Alzheimer's disease. It emphasizes that the pharmacological manipulation of astroglial production of NGF may serve as a possible therapeutic strategy to ameliorate the pathological changes occurring after brain damage.