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Dynamic magnetic resonance imaging for the evaluation of synovitis in patients with rheumatoid arthritis
K Tamai1, M Yamato, T Yamaguchi
1Dokkyo University School of Medicine, Tochigi, Japan.
Objective:
To investigate whether the findings of magnetic resonance imaging (MRI) reflect rheumatoid synovitis.
Methods:
Dynamic imaging enhanced with gadolinium-diethylenetriamine pentaacetic acid was performed on 10 affected knees of 9 patients with rheumatoid arthritis. Changes in signal intensity were correlated with pathologic findings in synovial biopsy specimens obtained during total knee arthroplasty.
Results:
Enhancement was greater in regions with a higher degree of fibrin exudation, cellular infiltration, villous hypertrophy, vascular proliferation, and granulation formation.
Conclusion:
Dynamic MRI can be used for assessing local disease activity in rheumatoid synovium.