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The role of the extracellular matrix in tumor cell metastasis
M L Stracke1, J Murata, S Aznavoorian
1Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
In Vivo (Athens, Greece)
|January 1, 1994
Abstract:
The extracellular matrix is a macromolecular network that surrounds cells and makes up a significant portion of their microenvironment. During the processes of invasion and metastasis, tumor cells encounter interstitial stroma and basement membranes many times. In fact, tumor cell response to extracellular matrix components appears to be a major determinant of metastatic potential.