[Antioxidative activity of drugs used in anticonvulsive therapy]

The influence of medicines used in anticonvulsive therapy: phenobarbital, diphenin, phenazepam and Na-valproate at ascorbate-(ASPOL) and NADP H-(PhPOL) depended lipid peroxidation (POL) in pattern systems (homogenates of rat's brain--HRB, lecithin liposomes-LL) has been studied. It has been established that this medicines do not influence at ASPOL in LL in concentration range of 10-10 M. Phenobarbital (10 M) and Na-valproate (10 M) inhibit ASPOL and PhPOL in HRB in 20-25%. Diphenin (10 M) and phenazepam' 10 M) inhibit both types of POL in HRB in 20-25%. Thus, tested medicines, being not the antioxidants themselves, influence at some components in POL regulating system in nerve tissue, inhibiting this process.