[Effect of hydrocortisone on the activity of lysosomal enzymes in skin]

The mechanisms of glucocorticoids' effect on the functional activity of lysosomes in rats dermis and epidermis have been studied. The activity of enzymes in both parts of skin in females was more than in ones in males. Intraperitoneal injection of hydrocortisone doesn't change the functional activity of lysosomes in skin in doses less than 1 mg per 100 g of weight apart from the sex of rats. The hormone in dose 1 mg/100 g of weight causes statistically reliable releasing of lysosomal glycosidases from the epidermis and dermis of both of the sex of rats, and cathepsin D in females as well. In experiments in vitro the concentration of hormone 10(-8) M causes the fall of possibility of enzymatic fission of substrates in dermis, but the concentration 10(-3) M causes the increasing of the one on the contrary. Enzymatic alterations in the results of action of glucocorticoids in dermis and in epidermis as in males so in females of rats and the causes of their distinguishes have been discussed.