On the antigenic diversity threshold model for AIDS
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N I Stilianakis1, D Schenzle, K Dietz
1Department of Medical Biometry, University of Tübingen, Germany.
Mathematical Biosciences
|June 1, 1994
Abstract:
In this paper stochastic simulations of a model for AIDS pathogenesis developed by Nowak and coworkers are presented. The results reveal a strong dependency on initial conditions, and the model predicts a nonmonotonic hazard rate for the transition to AIDS. Doubts are raised concerning the significance of the "antigenic diversity threshold," since it only partially characterizes the model dynamics.