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Related Experiment Videos

Drugs in semen

S Pichini1, P Zuccaro, R Pacifici

  • 1Clinical Biochemistry Unit, Istituto Superiore di Sanità, Rome, Italy.

Clinical Pharmacokinetics
|May 1, 1994
PubMed
Summary
This summary is machine-generated.

Many drugs are excreted into semen, potentially impacting male fertility and causing adverse effects. Further research and drug development evaluations are recommended to assess drug effects on semen quality.

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Area of Science:

  • Reproductive Medicine
  • Pharmacology
  • Toxicology

Background:

  • Semen quality has declined globally over the past 50 years, potentially reducing male fertility.
  • Drug exposure is a significant factor affecting semen quality, with drugs entering seminal plasma via ion-trapping.
  • Limited research exists on drug pharmacokinetics in male accessory glands and their effects on semen.

Purpose of the Study:

  • To review the current literature on drug excretion into semen.
  • To examine the potential impact of drugs in semen on male reproductive health and female recipients.
  • To recommend the inclusion of semen analysis in drug development.

Main Methods:

  • Literature review of studies examining drug concentrations in seminal plasma.

Related Experiment Videos

  • Analysis of research on the effects of specific drugs (e.g., mesalazine, propranolol, caffeine) on sperm physiology and morphology.
  • Evaluation of the ion-trapping mechanism for drug entry into the male genitourinary tract.

    • Main Results:

    • Evidence indicates that numerous drugs are excreted into semen.
    • These drugs can alter semen characteristics, potentially leading to male-mediated teratogenic effects.
    • Some drugs may cause local or systemic responses in female partners.

    Conclusions:

    • Drugs present in semen can negatively affect semen quality and male fertility.
    • Pharmacokinetic evaluation of drugs in semen and analysis of semen parameters should be integrated into drug development.
    • This is crucial for drugs known to concentrate in semen.