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[Neuropsychiatric symptoms in primary hyperparathyroidism]
W Schreiber1, M Kellner, M Heuser-Link
1Psychiatrische Abteilung, Klinisches Institut, Max-Planck-Institut für Psychiatrie.
Deutsche Medizinische Wochenschrift (1946)
|August 5, 1994
Summary
A case study highlights primary hyperparathyroidism as a cause of neuropsychiatric symptoms, including memory loss and disorientation. Surgical correction of the parathyroid adenoma resolved these symptoms, emphasizing the need to consider organic causes for neurological changes.
Area of Science:
- Endocrinology
- Neurology
- Neurosurgery
Background:
- Primary hyperparathyroidism is a condition characterized by excessive parathyroid hormone production.
- Neuropsychiatric symptoms can manifest in primary hyperparathyroidism, though often overlooked.
- This case examines the link between a parathyroid adenoma and a constellation of neurological and cognitive deficits.
Observation:
- A 51-year-old woman presented with a 3-month history of depressive syndrome, memory loss, anomia, impaired fine motor skills, and spatial disorientation.
- Biochemical tests revealed mild elevations in serum calcium and parathyroid hormone levels.
- Thyroid ultrasonography indicated a right cranial parathyroid adenoma.
Findings:
- Surgical resection of the right upper parathyroid adenoma was performed.
- Post-operatively, serum calcium and parathyroid hormone levels normalized.
- Neuropsychiatric symptoms resolved within two months following surgery.
Implications:
- This case underscores the importance of considering primary hyperparathyroidism in patients with unexplained neuropsychiatric symptoms.
- Early diagnosis and treatment of parathyroid adenomas can lead to significant improvement in neurological and cognitive function.
- Highlights the need for a multidisciplinary approach in diagnosing complex cases with overlapping endocrine and neurological features.