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Vitreous substitution with gases

I J Constable, D A Swann

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |June 1, 1975
    PubMed
    Summary

    Vitreous substitution with gases like sulfur hexafluoride and octafluorocyclobutane increased ocular vascular permeability in owl monkeys more than saline. This effect

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    Area of Science:

    • Ophthalmology
    • Vascular Biology
    • Ocular Physiology

    Background:

    • Vitreous humor plays a crucial role in maintaining ocular structure and function.
    • Understanding the impact of different vitreous substitutes on ocular physiology is essential for surgical interventions.

    Purpose of the Study:

    • To compare the effects of various vitreous substitutes on ocular vascular permeability in owl monkeys.
    • To investigate the relationship between the duration of gas tamponade and vascular permeability.

    Main Methods:

    • Vitreous substitution in owl monkeys using air, sulfur hexafluoride-air mixture, octafluorocyclobutane-air mixture, and physiological saline.
    • Measurement of ocular vascular permeability via vitreous inflow of iodine I 131-labeled serum protein.
    • Analysis of protein composition using disc gel electrophoresis.

    Main Results:

    • All tested gases significantly increased ocular vascular permeability compared to physiological saline.
    • The magnitude of increased vascular permeability correlated with the specific gas used.
    • The duration of elevated vascular permeability was directly proportional to the intraocular retention time of the gas.

    Conclusions:

    • Gaseous vitreous substitutes can induce a transient increase in ocular vascular permeability.
    • The choice of tamponade gas may influence post-operative ocular fluid dynamics and healing.
    • Further research is warranted to elucidate the precise mechanisms and clinical implications.

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