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Induction of respiration-deficient mutants in Saccharomyces cerevisiae by chelerythrine
V Krivjanský1, M Obernauerová, J Ulrichová
1Department of Microbiology and Virology, Faculty of Sciences, Comenius University, Bratislava, Slovak Republic.
FEMS Microbiology Letters
|July 1, 1994
Abstract:
Chelerythrine and sanguinarine, two structurally related benzo/c/phenanthridine alkaloids, prevented growth of yeast cells in medium containing either glucose or non-fermentable carbon sources. At concentrations permitting growth of the yeast Saccharomyces cerevisiae, chelerythrine, but not sanquinarine, induced cytoplasmic respiration-deficient mutants. The petite clones that were analysed exhibited suppressiveness and contained different fragments of the wild-type mitochondrial genome.