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A circulating renin activator in essential hypertension

M P Sambhi, P Eggena, J C Barrett

Circulation Research

|June 1, 1975

Summary

Hypertension patients show higher angiotensin generation rates due to an "activated" plasma modifier. This modifier acts as an uncompetitive activator in the renin-angiotensin system, impacting blood pressure regulation.

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Area of Science:

Biochemistry
Physiology
Hypertension Research

Background:

Plasma angiotensin generation is crucial in blood pressure regulation.
Benign essential hypertension is associated with altered renin-angiotensin system activity.

Purpose of the Study:

To investigate the angiotensin generation rate in hypertensive patients.
To identify factors contributing to
activated
plasma in hypertension.
To characterize the nature of plasma modifiers affecting the renin reaction.

Main Methods:

Measurement of angiotensin generation rate using added renin in patient and control plasma.
Definition and application of a plasma renin substrate (PRS-r) index.

Related Experiment Videos

Use of an isolated human renin and renin substrate system to study plasma modifiers.

Kinetic analysis (V-max, Km) of the renin reaction in the presence of hypertensive plasma.

Main Results:

Hypertensive patients exhibited a significantly higher PRS-r index compared to normotensive controls.
The PRS-r index did not correlate with blood pressure, sodium excretion, or plasma renin activity.
Plasma from hypertensive subjects contains an uncompetitive activator of the renin reaction, increasing V-max and Km.
Normal plasma did not significantly alter the isolated renin-renin substrate system.

Conclusions:

Plasma from patients with benign essential hypertension contains a modifier that enhances angiotensin generation.
This modifier acts as an uncompetitive activator in the renin reaction, suggesting a novel mechanism in hypertension.
The PRS-r index is a valuable tool for screening "activated" plasma in hypertensive individuals.