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Clinical trial of pentazocine as analgesic in paediatric cases
Insights
Pentazocine effectively relieved peri-operative pain in children aged 5-9 years undergoing surgery. The study found satisfactory analgesia with no significant adverse effects like respiratory depression.
Area of Science:
- Anesthesiology
- Pediatric Surgery
- Pain Management
Background:
- Peri-operative pain in children is often poorly understood and managed.
- Effective analgesia is crucial for pediatric surgical patients.
Purpose of the Study:
- To evaluate the analgesic efficacy of pentazocine in children undergoing surgery.
- To assess the safety profile of pentazocine in this pediatric population.
Main Methods:
- A study involving 50 children aged 5-9 years undergoing major and minor surgeries.
- Intravenous pentazocine administered during induction (0.5 mg/kg) and incrementally during surgery.
- No premedication was used to isolate the drug's effect.
Main Results:
- Satisfactory analgesia was achieved during both intra-operative and post-operative periods.
- No instances of respiratory depression were observed.
- No significant changes in pulse or blood pressure were noted.
Conclusions:
- Intravenous pentazocine is an effective analgesic for pediatric patients during surgery.
- Pentazocine demonstrates a favorable safety profile in children, with no observed complications.
Abstract:
This study was undertaken with the objective of relieving pain which has been poorly understood and managed in peri-operative period specially in children. Here the analgesic efficacy of pentazocine was studied in 50 cases, aged between 5 and 9 years subjected to both major and minor surgeries. No premedication was given to assess the sole analgesic effect of the drug. Pentazocine was given during induction, dose being 0.5 mg/kg body weight intravenously. Subsequently small incremental doses were repeated after every 30-45 minutes during surgery. Satisfactory analgesia was obtained during intra- and postoperative period. No respiratory depression, no change in pulse, BP and no other complications were observed after administration of intravenous pentazocine.