Endogenous variations and sodium intake-dependent components of diurnal sodium excretion patterns in dogs

1. Automated, sequential, 20 min urine collections were made to provide a record of diurnal variations of urinary sodium excretion (UNaV) in seven dogs, in which the same daily intake of sodium, potassium and water was administered, at first orally (between 08.30 and 08.50 h) on day 1 and then by i.v. infusion at a constant rate on days 2 and 3. This basic protocol was employed for two different levels of sodium intake: normal (NSI; 2.5 mmol (kg body wt)-1 (24 h)-1) and high (HSI; 14.5 mmol (kg body wt)-1 (24 h)-1). 2. The aims were: firstly, to establish the diurnal pattern of UNaV under these circumstances; secondly, to find out whether the quantity of sodium administered influences this diurnal pattern; and thirdly, to distinguish endogenous fluctuations from intake-dependent components in the UNaV excretion patterns. 3. On day 1 (oral intake) all dogs exhibited a similar excretion pattern, which peaked between 13.00 and 15.00 h on both diets and then diminished again over the remainder of the 24 h period. 4. On days 2 and 3 (infusion) UNaV fluctuated within a considerable range. 5. On HSI, the maximal UNaV rates on day 1 were about double those observed on infusion days. On HSI, UNaV during infusion days seems to consist of a constant basal component of about 5-6 mumol (kg body wt)-1 min-1 upon which a fluctuating component is superimposed. The basal component may be a reactive homeostatic response to the high sodium intake, whereas the superimposed fluctuating component may reflect endogenous variations.(ABSTRACT TRUNCATED AT 250 WORDS)