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[Vitamin A status in patients with cholelithiasis]
1Department of Clinical Biochemistry, Kaohsiung Medical College, Taiwan, Republic of China.
Gaoxiong Yi Xue Ke Xue Za Zhi = the Kaohsiung Journal of Medical Sciences
|June 1, 1994
Summary
Adults with cholelithiasis (gallstones) frequently experience vitamin A deficiency. This study found significantly lower vitamin A levels in patients with gallstones, highlighting the need for evaluation and treatment.
Area of Science:
- Biochemistry
- Nutritional Science
- Gastroenterology
Context:
- Cholelithiasis (gallstones) affects a significant portion of the adult population.
- Vitamin A deficiency can lead to various health complications, including visual impairment and immune dysfunction.
- The relationship between cholelithiasis and vitamin A status has not been extensively studied.
Purpose:
- To assess vitamin A status in adults with cholelithiasis.
- To determine the frequency of vitamin A deficiency in this patient group.
- To compare vitamin A levels in patients with and without jaundice, and with healthy controls.
Summary:
- Plasma vitamin A levels were significantly lower in 64 patients with cholelithiasis compared to 40 healthy subjects (P < 0.05).
- Liver tissue vitamin A levels also showed significant differences between patient groups (P < 0.05).
- Vitamin A deficiency (plasma level < 90 µg/dL) was observed in 50% of cholelithiasis patients, including 65% of jaundiced and 25% of anicteric patients.
Impact:
- Biochemical vitamin A deficiency is common in patients with cholelithiasis.
- Routine evaluation of vitamin A levels is recommended for patients diagnosed with cholelithiasis.
- Timely intervention and therapy are crucial to prevent complications associated with vitamin A deficiency in this population.