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A human immunodeficiency virus type 1 (HIV-1)-based retroviral vector system utilizing stable HIV-1 packaging cell
R Carroll1, J T Lin, E J Dacquel
1Research Laboratory, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland.
Journal of Virology
|September 1, 1994
Abstract:
We have constructed stable human immunodeficiency virus (HIV) packaging cell lines that when transfected with an HIV-based retroviral vector produce packaged vectors capable of transducing susceptible CD4+ cells. This HIV-1-based retroviral vector system has the potential for providing targeted delivery and regulated expression of immunogens or antiviral agents in CD4+ cells.