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[Influence of ionized calcium concentration during cardiopulmonary bypass on pediatric cardiac surgery]
N Atsumi1, M Abe, Y Sakakibara
1Department of Surgery, University of Tsukuba, Japan.
Insights
Serum ionized calcium (Ca2+) levels drop during cardiopulmonary bypass (CPB) in pediatric patients. Supplementing with calcium chloride during priming prevents this drop, ensuring stable Ca2+ levels during cardiac surgery.
Area of Science:
- Cardiovascular Surgery
- Pediatric Cardiology
- Biochemistry
Abstract:
Changes of serum ionized calcium concentration (Ca2+) during cardiopulmonary bypass (CPB) were analyzed in 30 pediatric cardiac patients less than 15 kg body weight. Ca2+ decreased suddenly after the start of CPB, and it gradually increased to the normal value. Citrate added to the stored blood for priming and its metabolism might play a role in these changes of Ca2+. Addition of adequate volume of calcium chloride to the priming prevented sudden decrease of Ca2+. Although addition of citrate before aortic declamp effectively decreased Ca2+ and may prevent reperfusion cardiac injury associated with hypercalcemia, there were no correlation between predeclamp level of Ca2+ and serum CPK and GOT levels.