Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mitochondrial inheritance and disease

P E Fine

    Lancet (London, England)
    |September 23, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Mitochondrial DNA variants may cause human diseases, especially blood disorders linked to chloramphenicol. These conditions, inherited maternally, appear in related individuals and depend on mitochondrial distribution during development.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Mixture analysis of tuberculin survey data from northern Malawi and critique of the method.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2006
    Same author

    Stopping a polio outbreak in the post-eradication era.

    Developments in biologicals·2002
    Same author

    Comparison of two versus three smears in identifying culture-positive tuberculosis patients in a rural African setting with high HIV prevalence.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2001
    Same author

    Field-based random sampling without a sampling frame: control selection for a case-control study in rural Africa.

    Transactions of the Royal Society of Tropical Medicine and Hygiene·2001
    Same author

    The development of the HIV epidemic in Karonga District, Malawi.

    AIDS (London, England)·2001
    Same author

    Environmental mycobacteria in northern Malawi: implications for the epidemiology of tuberculosis and leprosy.

    Epidemiology and infection·2001
    Same journal

    Assisted dying and the silencing of medicine's next generation.

    Lancet (London, England)·2026
    Same journal

    Linguistic pragmatism: a woman with progressive abdominal pain in Thailand.

    Lancet (London, England)·2026
    Same journal

    Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

    Lancet (London, England)·2026
    Same journal

    [<sup>177</sup>Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial.

    Lancet (London, England)·2026
    Same journal

    Research priorities for characterising Bundibugyo virus.

    Lancet (London, England)·2026
    Same journal

    Rethinking treatment sequence in advanced gastroenteropancreatic neuroendocrine tumours.

    Lancet (London, England)·2026
    See all related articles

    Area of Science:

    • Mitochondrial genetics
    • Human disease etiology
    • Pharmacogenomics

    Background:

    • Mitochondria possess their own DNA (mtDNA) which can undergo spontaneous mutations.
    • Mitochondrial dysfunction is implicated in various human pathologies.
    • Certain drug toxicities, like chloramphenicol-induced blood dyscrasias, suggest a mitochondrial role.

    Purpose of the Study:

    • To explore the potential role of mitochondrial DNA (mtDNA) variants in human diseases.
    • To investigate the hypothesis that drug-induced blood dyscrasias, specifically chloramphenicol toxicity, may stem from mtDNA defects.
    • To understand the inheritance patterns and developmental factors influencing the manifestation of mitochondrial diseases.

    Main Methods:

    • Analysis of mtDNA in patients with suspected mitochondrial disorders.

    Related Experiment Videos

  • Review of clinical data for drug-induced blood dyscrasias.
  • Pedigree analysis to trace maternal inheritance patterns.
  • Developmental biology principles applied to mitochondrial distribution.

    • Main Results:

    • Spontaneous mtDNA variants are proposed as a cause of human disease.
    • Chloramphenicol-induced blood dyscrasias are highlighted as a key candidate for mitochondrial etiology.
    • Matroclinous inheritance is predicted for such mitochondrial disorders.
    • Clinical presentation is linked to the developmental allocation of mitochondria to tissues.

    Conclusions:

    • Mitochondrial DNA mutations represent a significant etiological factor in human diseases.
    • Drug-induced blood dyscrasias, particularly chloramphenicol toxicity, warrant further investigation as mitochondrial disorders.
    • Understanding maternal inheritance and developmental mitochondrial distribution is crucial for diagnosing and managing these conditions.