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Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis
P Rieckmann1, M Albrecht, B Kitze
1Department of Neurology, University of Göttingen, Germany.
Neurology
|August 1, 1994
Abstract:
We determined the cytokine messenger RNA (mRNA) expression pattern of blood mononuclear cells in 45 patients with the relapsing-remitting form of MS and 32 patients with other neurologic diseases. Using a semiquantitative polymerase chain reaction method, we detected significantly higher levels of tumor necrosis factor-alpha and lymphotoxin mRNA in patients with relapsing compared to those with stable disease (p < 0.001), but transforming growth factor-beta and interleukin-10 mRNA expressions were higher in patients with stable disease.