[Isotopic composition of blood plasma carbon in patients with endocrine diseases]

Forty-eight patients suffering from diabetes mellitus, obesity, hyper- and hypothyrosis, Icenko-Cushing's disease were examined to elucidate the relationship between blood plasma carbon isotopic composition and the type of the endocrine disease. This value varied within the range of -19.7 to -24.7/1000, the mean value being 5/1000. Blood plasma carbon in the diabetics is enriched for 12C light isotope (delta 13C from -23.0 to -24.5/1000) as against a similar characteristic in obese patients (delta 13C from -20.5 to 21.99/1000). Patients with hypo- and hyperthyrosis and the Icenko-Cushing's disease have a wider range of delta 13C values that seems to be explained by the Icenko-Cushing's disease heterogeneity and the presence of biorhythms. Clear-cut isotopic differences in the blood sera of adults and children were revealed whatever the disease type, these differences indicating the changes in cellular metabolism energy in the ontogenesis. These data can be satisfactorily explained within the frames of the model of cellular division of carbon isotopes, suggested previously.