[Endocrine regulation of chlorine ion transport in rat kidneys]

Eighty-five intact, adrenalectomized and hypophysectomized white male rats fed low-caloric diets were used in experiments. Hormonal effects on urinary excretion of chlorides and sodium were studied in hyperhydration conditions; these hormones' levels are elevated in metabolic acidosis. Experiments have demonstrated that corticotropin in intact animals and hydrocortisone in hypophysectomized ones increased chlorine ions elimination without increasing sodium withdrawal. On the contrary, adrenal- and hypophysectomy reduced Cl- excretion without changing Na+ excretion. Vasopressin and insulin increased Na+ excretion and, to a much greater measure, Cl- excretion. The author comes to a conclusion that urinary excretion of chlorine ions not bound to sodium, conducive to accumulation in the blood of bicarbonate, is regulated in metabolic acidosis by corticotropin, glucocorticoids, vasopressin, and insulin.