Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The dose-response relationship for hypoxic pulmonary vasoconstriction

B E Marshall1, W R Clarke, A T Costarino

  • 1Center for Anesthesia Research, Hospital of the University of Pennsylvania, Philadelphia 19104.

Respiration Physiology
|May 1, 1994
PubMed
Summary

Hypoxic pulmonary vasoconstriction in dogs was quantified. The study derived a formula for stimulus oxygen tension and a dose-response curve for pulmonary vascular resistance, reconciling previous findings.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fox on the Run-Cheaper Camera Traps Fail to Detect Fast-Moving Mesopredators: Assessing the Differences in Mesopredator Detection Efficacy Among Different Camera Trap Models.

Ecology and evolution·2025
Same author

Measurement of Electron Antineutrino Oscillation Amplitude and Frequency via Neutron Capture on Hydrogen at Daya Bay.

Physical review letters·2024
Same author

MEN2 phenotype in a family with germline heterozygous rare RET K666N variant.

Endocrinology, diabetes & metabolism case reports·2024
Same author

Search for a Sub-eV Sterile Neutrino Using Daya Bay's Full Dataset.

Physical review letters·2024
Same author

High Resolution Study of ^{40}Ca to Constrain Potassium Nucleosynthesis in NGC 2419.

Physical review letters·2024
Same author

Improved Measurement of the Evolution of the Reactor Antineutrino Flux and Spectrum at Daya Bay.

Physical review letters·2023

Area of Science:

  • Physiology
  • Pulmonary Circulation
  • Respiratory System

Background:

  • Hypoxic pulmonary vasoconstriction (HPV) is a critical mechanism for matching ventilation and perfusion in the lungs.
  • Previous studies have yielded varied results regarding the precise quantification and governing factors of HPV.

Purpose of the Study:

  • To derive a three-dimensional response surface for HPV in canine lungs.
  • To establish a quantitative dose-response relationship for HPV.

Main Methods:

  • Independent ventilation of canine lungs with 100% oxygen in one lung.
  • Perfusion of the contralateral lung with controlled oxygen tension.
  • Recording of pulmonary artery and left atrial pressures during constant flow.
  • Derivation of a response surface and dose-response sigmoid equation.

Related Experiment Videos

Main Results:

  • The maximum increase in pulmonary vascular resistance (r%PVRmax) was 3.15-fold at a stimulus oxygen tension (PSO2) of 10 mmHg.
  • The stimulus oxygen tension was defined as PSO2 = PVO2(0.41) x PAO2(0.59).
  • A sigmoid dose-response equation for HPV was derived: r%PVRmax = 100 (PSO2(-2.616))/(6.683 x 10(-5) + PSO2(-2.616)).

Conclusions:

  • The derived response surface and dose-response equation provide a unified framework for understanding HPV in canine lungs.
  • These findings reconcile observations from multiple laboratories and have broad applicability.