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Updated: Aug 10, 2026

Rapid Generation of Amyloid from Native Proteins In vitro
Published on: December 6, 2013
[Hereditary amyloidosis]
1Praticien hospitalier universitaire, service de médecine interne, Hôtel-Dieu de Paris, France.
Abstract:
Amyloidoses are characterized by the deposition of non soluble proteins in tissues. Clinical aspects of hereditary amyloidoses are very diverse, and they offer many diagnosis problems to the physician. Biochemical and genetic aspects are also various. Several proteins are implicated in these hereditary diseases mainly: transthyretin, apolipoprotein A1, gelsolin, fibrinogen alpha chain and lysozyme. Studies on structural changes induced by the mutations in the transthyretin should bring new data relevant to our understanding of the amyloidogenic process. Transgenic mice with mutated transthyretin are a good model and will allow new pathogenic approach and therapeutic intervention.
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