Related Experiment Video
Updated: Aug 7, 2026

Novel Passive Clearing Methods for the Rapid Production of Optical Transparency in Whole CNS Tissue
Published on: May 8, 2018
[Erythrocyte transketolases and Alzheimer disease]
J Eisinger1, P Arroyo, M Braquet
1Service de rhumatologie et médecine gériatrique, hôpital Georges-Clémenceau, Toulon, France.
Abstract:
Abnormalities of thiamin metabolism have been reported in senile dementia of Alzheimer's type (SDAT). Transketolases (TK) were studied in 21 patients with SDAT, 24 age-matched controls and 12 chronic alcoholics. Erythrocytes were assessed for their TK activity coefficient (TK-AC, normal value 8.4 +/- 12.6%) and affinity for thaimin pyrophosphate (Km TPP, normal value 17.8 +/- 8.3 mumol). Comparison between study groups and controls demonstrated increased TK-AC in SDAT (16.6 +/- 15.7%, P < 0.05) and chronic alcoholism (43.4 +/- 40.6%, P < 0.05), and increased Km TPP (38.3 +/- 25.2 mumol, P < 0.01) in SDAT only. These findings suggest structural abnormalities of TK rather than vitamin B1 deficiency in SDAT.
More Related Videos
08:48Using Live Cell STED Imaging to Visualize Mitochondrial Inner Membrane Ultrastructure in Neuronal Cell Models
Published on: June 30, 2023
11:57Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase
Published on: June 24, 2025
Related Concept Videos
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...
Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer Disease l: Introduction
Alzheimer Disease ll: Pathophysiology