Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[HLA class I and II antigens and diffuse toxic goiter]

A P Kalinin, T S Kamynina, Iu M Zaretskaia

    Terapevticheskii Arkhiv
    |January 1, 1993
    PubMed
    Summary

    Human Leukocyte Antigen (HLA) antigen associations were identified in patients with diffuse toxic goiter. Certain HLA antigens correlate with disease severity and recurrence, with HLA B8 linked to endocrine ophthalmopathy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [The analysis of concentration of cyclosporine A in blood using liquid chromatographic mass spectrometry].

    Klinicheskaia laboratornaia diagnostika·2013
    Same author

    [Hyper- and hypoaldosteronism].

    Klinicheskaia meditsina·2008
    Same author

    [The modern potential of histocompatibility in clinical kidney transplantation].

    Vestnik Rossiiskoi akademii meditsinskikh nauk·2006
    Same author

    [Adrenal gland surgery].

    Vestnik Rossiiskoi akademii meditsinskikh nauk·2006
    Same author

    Vascular endothelium growth factor in the sera of patients with adrenal tumors.

    Bulletin of experimental biology and medicine·2005
    Same author

    [Diabetes mellitus and the heart].

    Klinicheskaia meditsina·2005

    Area of Science:

    • Immunogenetics
    • Endocrinology
    • Molecular Biology

    Background:

    • Diffuse toxic goiter, an autoimmune thyroid disease, involves complex genetic factors.
    • Human Leukocyte Antigen (HLA) genes are crucial for immune response and have been implicated in various autoimmune conditions.

    Purpose of the Study:

    • To investigate the association between specific HLA class I and II antigens and the incidence of diffuse toxic goiter.
    • To determine if particular HLA antigen profiles correlate with disease severity, recurrence, or associated complications like endocrine ophthalmopathy.

    Main Methods:

    • Analysis of HLA class I and II antigen frequencies in a cohort of 168 patients with diffuse toxic goiter.
    • Statistical comparison of antigen prevalence between patients and control groups (implied).

    Related Experiment Videos

  • Correlation analysis between specific HLA antigens and clinical parameters such as thyrotoxicosis severity, recurrence, and endocrine ophthalmopathy.

    • Main Results:

    • Significant positive associations were found for HLA antigens A2, A3, A28, B8, B15, B17, Cw4, and DR5.
    • Negative associations were observed with HLA antigens A24, Bw4, Bw6, Cw1, Cw2, Cw3, Cw5, and DR9.
    • HLA antigens B15, B17, Cw4, and DR5 prevalence correlated with thyrotoxicosis severity; HLA A2 was associated with recurrent toxic goiter. HLA B8 was identified as a marker for endocrine ophthalmopathy.

    Conclusions:

    • Specific HLA class I and II antigen profiles are associated with diffuse toxic goiter.
    • Certain HLA antigens serve as predictive markers for disease severity, recurrence, and the development of endocrine ophthalmopathy.
    • These findings contribute to understanding the immunogenetic basis of diffuse toxic goiter and its clinical manifestations.