Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Genetic approaches to Itsenko-Cushing disease]

A P Kalinin, A B Andrusenko, A V Novikov

    Terapevticheskii Arkhiv
    |January 1, 1993
    PubMed
    Summary

    This study investigated the genetic basis of Itsenko-Cushing disease, revealing hereditary links and multifactorial inheritance patterns. Findings suggest genetic determination in some forms and associations with other conditions like hypertension.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [THE SOCIAL POLICY OF ST. PETERSBURG IN THE FIELD OF HEALTH CARE].

    Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny·2026
    Same author

    [Development of prognostic clinical and genetic models of the risk of low bone mineral density using neural network training].

    Problemy endokrinologii·2025
    Same author

    [Challenges in diagnosing familial Mediterranean fever: exploring atypical clinical features. Clinical case].

    Terapevticheskii arkhiv·2024
    Same author

    Gamma-ray dose threshold for MAPbI<sub>3</sub> solar cells.

    Physical chemistry chemical physics : PCCP·2024
    Same author

    Light-emitting diodes with Ge(Si) nanoislands embedded in photonic crystals.

    Nanotechnology·2024
    Same author

    [The analysis of secondary AA-amyloidosis current etiology and its influence on the approaches for diagnosis and treatment].

    Terapevticheskii arkhiv·2022

    Area of Science:

    • Endocrinology
    • Genetics
    • Immunology

    Background:

    • Itsenko-Cushing disease (ICD) presents complex etiological factors.
    • Understanding the hereditary components of ICD is crucial for diagnosis and management.

    Purpose of the Study:

    • To investigate the hereditary predisposition and genetic factors in Itsenko-Cushing disease.
    • To explore associations between ICD, other diseases, and human leukocyte antigen (HLA) profiles.

    Main Methods:

    • Clinico-genealogical analysis of 107 ICD patients.
    • Family history assessment in 75 patients.
    • Dermatoglyphic analysis in 44 patients.
    • HLA antigen typing (Class I and II) in 68 patients.

    Main Results:

    Related Experiment Videos

    • Significant hereditary loading for ICD and associated conditions (hypertension, atherosclerosis, autoimmune disorders) was observed.
    • Autosomal recessive and dominant inheritance patterns were identified in specific ICD forms.
    • Multifactorial inheritance was suggested by HLA associations (DR4, DR5, DR7, DRw53, DQw3).

    Conclusions:

    • Itsenko-Cushing disease exhibits genetic determination in certain forms.
    • ICD is associated with hypertension and atherosclerosis, suggesting shared genetic or environmental factors.
    • Recommendations for detailed family history collection in ICD patients were developed for improved prognosis and classification.