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[The effect of different antimicrobial preparations on the normalization of the intestinal microflora in patients
Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
|March 1, 1993
Abstract:
These investigations revealed that the treatment of patients with generalized peritonitis with ampiox, gentamicin and metronidazole, as well as with cephalosporins and metronidazole, led to the aggravation of dysbiotic disturbances in normal intestinal microflora, observed in these patients before treatment. Ciprofloxacin had a selective decontaminating effect on the intestine, which facilitated the decrease of suppuration in postoperative wounds.
Insights
Antibiotic treatment for peritonitis worsened gut bacteria imbalances. Ciprofloxacin, however, selectively cleared the gut, reducing wound infections.
Area of Science:
- Microbiology
- Clinical Medicine
- Pharmacology
Background:
- Generalized peritonitis patients often exhibit intestinal microflora dysbiosis.
- Standard antibiotic regimens may exacerbate these pre-existing microbial imbalances.
Purpose of the Study:
- To evaluate the impact of different antibiotic treatments on intestinal microflora in generalized peritonitis patients.
- To assess the effect of ciprofloxacin on postoperative wound suppuration.
Main Methods:
- Patients with generalized peritonitis received treatments including ampiox, gentamicin, metronidazole, cephalosporins, and metronidazole.
- The study monitored changes in intestinal microflora composition.
- Postoperative wound outcomes were analyzed in relation to antibiotic treatment.
Main Results:
- Ampiox, gentamicin, and metronidazole, as well as cephalosporins and metronidazole, aggravated intestinal dysbiosis.
- Ciprofloxacin demonstrated a selective decontaminating effect on the intestinal tract.
- This selective decontamination by ciprofloxacin correlated with a reduction in postoperative wound suppuration.
Conclusions:
- Certain common antibiotic combinations worsen gut dysbiosis in peritonitis patients.
- Ciprofloxacin offers a potential therapeutic advantage by selectively reducing intestinal microbial load and improving surgical outcomes.