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Partial development of the corpus callosum
D Rubinstein1, V Youngman, J H Hise
1University of Colorado Health Sciences Center, Department of Radiology, Denver 80262.
Purpose:
To determine whether the MR findings of callosal dysgenesis suggest that the partially formed corpus callosum in humans is the result of arrested growth or delayed continued development.
Methods:
The MR scans of 25 patients with callosal dysgenesis were reviewed to determine whether the observed corpus callosum corresponded to the form and position of a portion of a normal corpus callosum, as suggested by a theory of arrested growth.
Results:
In 10 of the 25 cases, the partially formed corpus callosum corresponded to a portion of a normal corpus callosum. In the remaining 15 cases, the partially formed corpus callosum was located posterior to the expected location of a normal genu and inferior to the expected location of a normal body.
Conclusions:
Corpus callosum dysgenesis in humans may be caused by arrested growth in some cases; in other cases it is most likely caused by delayed continued development that attempts to compensate for earlier abnormalities in the evolution of midline structures.