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Failure of schistosomiasis to significantly decrease testosterone levels in Brazilian men

P J Skelly1, W E Secor, M G Reis

  • 1Department of Tropical Public Health, Harvard School of Public Health, Boston, Massachusetts.

The American Journal of Tropical Medicine and Hygiene
|July 1, 1994
PubMed
Summary
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Schistosomiasis infection in human males does not typically cause castration. Studies found normal testosterone levels in infected individuals, unlike in rodent models.

Area of Science:

  • Parasitology
  • Endocrinology
  • Tropical Medicine

Background:

  • Schistosomes are known to castrate invertebrate and vertebrate hosts.
  • The effect of Schistosoma mansoni infection on human male reproductive health is not fully understood.

Purpose of the Study:

  • To investigate whether Schistosoma mansoni infection leads to castration in human males.
  • To examine the relationship between infection severity and testosterone levels.

Main Methods:

  • Serum testosterone levels were measured in 38 Brazilian males (16-35 years) with Schistosoma mansoni infections.
  • Parasite load was estimated using fecal egg counts.
  • Testosterone levels were compared between infected individuals and noninfected controls.

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Main Results:

  • Individuals with intestinal schistosomiasis showed normal serum testosterone levels, similar to controls.
  • Four subjects with severe hepatosplenic disease also had normal testosterone levels.
  • A negative correlation between parasite load and testosterone was observed, but confounded by age.

Conclusions:

  • Host castration is not a usual side effect of human schistosomiasis.
  • Unlike rodent models, Schistosoma mansoni infection does not appear to significantly impact testosterone levels in human males.