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Infantile bilateral striatal necrosis: chronic and acute manifestations in a single case
M Mizuguchi1, I Usuda, A Yoneyama
1Department of Pediatrics, Faculty of Medicine, University of Tokyo, Japan.
Brain & Development
|January 1, 1994
Insights
A child developed a progressive movement disorder in infancy, showing brain atrophy on CT scans. An acute episode at age 6 revealed basal ganglia lesions, indicating severe neurological deterioration.
Area of Science:
- Pediatric Neurology
- Neurodegenerative Diseases
- Neuroimaging
Background:
- Extrapyramidal disorders can manifest in early childhood.
- Progressive neurological decline necessitates accurate diagnosis and understanding of underlying pathology.
- Cerebral atrophy and basal ganglia involvement suggest specific neurodegenerative processes.
Abstract:
We report a girl who exhibited a slowly progressive extrapyramidal disorder with onset in early infancy. CT examinations demonstrated progressive atrophy of the cerebrum. At the age of 6 years, acute exacerbation occurred with impairment of consciousness and autonomic functions. During the acute episode, CT revealed lesions in the bilateral striatum and globus pallidus.