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[Comparative clinical effectiveness and tolerance of azithromycin (sumamed) and erythromycin in patients with
Abstract:
Clinical efficacy of azithromycin and erythromycin was compared in an open trial in 32 and 18 patients with acute sinusitis respectively. The following pathogens were isolated: Haemophilus influenzae (29.8 per cent), Streptococcus pneumoniae (19.1 per cent), Staphylococcus aureus (10.6 per cent), Streptococcus faecalis (8.5 per cent) and other microbes (8.5 per cent). Azithromycin was administered in a dose of 500 mg on day 1. During the following 4 days it was administered in a dose of 250 mg. Erythromycin was administered in a dose of 500 mg 4 times a day for 8 to 10 days. 91.2 per cent of the aerobic microflora were sensitive to azitromycin and 85.3 per cent were sensitive to erythromycin. One of 14 strains of H. influenzae proved to be resistant to azithromycin, 3 strains were resistant to erythromycin. Complete recovery was stated in 90.6 per cent of the cases treated with azithromycin and 66.7 per cent of the cases treated with erythromycin.
Insights
Azithromycin demonstrated higher clinical efficacy in treating acute sinusitis compared to erythromycin. This macrolide antibiotic achieved a significantly higher recovery rate in patients with bacterial sinusitis.
Area of Science:
- Infectious Diseases
- Pharmacology
- Microbiology
Background:
- Acute sinusitis is a common condition often caused by bacterial infections.
- Macrolide antibiotics like azithromycin and erythromycin are frequently used for treatment.
- Comparative efficacy data is crucial for optimizing treatment protocols.
Purpose of the Study:
- To compare the clinical efficacy of azithromycin and erythromycin in patients with acute sinusitis.
- To evaluate the antimicrobial susceptibility of common sinusitis pathogens to these agents.
Main Methods:
- An open-label clinical trial involving 32 patients treated with azithromycin and 18 with erythromycin.
- Identification and susceptibility testing of isolated pathogens, including Haemophilus influenzae and Streptococcus pneumoniae.
- Dosage regimens: Azithromycin (500 mg day 1, then 250 mg days 2-5); Erythromycin (500 mg QID for 8-10 days).
Main Results:
- Azithromycin showed higher sensitivity rates against isolated aerobic microflora (91.2%) compared to erythromycin (85.3%).
- Complete recovery rates were significantly higher with azithromycin (90.6%) than with erythromycin (66.7%).
- Limited resistance was observed for H. influenzae to azithromycin (1/14 strains).
Conclusions:
- Azithromycin is a more effective treatment option for acute sinusitis than erythromycin.
- The observed efficacy supports azithromycin's role in managing bacterial sinusitis, considering its favorable susceptibility profile.