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Hyperthermia and endorphins

P P Vescovi1, V Coiro

  • 1Istituto di Clinica Medica Generale e Terapia Medica, Università di Parma, Italy.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|January 1, 1993
PubMed
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Opioid responses to heat stress are altered in addicts. Chronic drug or alcohol use disrupts the body's natural beta-endorphin and ACTH release, impairing heat adaptation in the central nervous system.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Toxicology

Background:

  • Endogenous opioids, specifically endorphins, play a role in the central nervous system's adaptation to heat.
  • Hyperthermia triggers the pituitary secretion of beta-endorphin and ACTH, serving as a measure of opioid function.
  • Previous research indicates potential alterations in opioid responses in individuals with substance use disorders.

Purpose of the Study:

  • To investigate the role of endogenous opioids in hyperthermia response.
  • To examine how drug or alcohol addiction affects opioid reactivity to thermal stress.
  • To assess beta-endorphin and ACTH responses to heat in healthy individuals versus addicts.

Main Methods:

  • Literature review of studies examining opioid responses to thermal stress (e.g., sauna).

Related Experiment Videos

  • Analysis of beta-endorphin and ACTH secretion patterns in response to hyperthermia.
  • Comparison of responses between healthy subjects and individuals with a history of heroin, cocaine, or alcohol addiction.

    • Main Results:

    • Healthy individuals show expected beta-endorphin and ACTH release in response to thermal stress.
    • Individuals addicted to heroin, cocaine, or alcohol exhibit blunted or absent beta-endorphin and ACTH responses to heat.
    • This suggests a disruption in opioid reactivity to hyperthermia in toxicomania.

    Conclusions:

    • Long-term stimulation of hypothalamic opioid neurotransmission by addictive substances disrupts the normal opioid response to thermal stress.
    • This disruption impairs the body's ability to adapt to heat in individuals with drug or alcohol addiction.
    • Opioid system alterations in addiction impact physiological responses beyond addiction itself.