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Monoamine metabolites in the cerebrospinal fluid in infantile spinal muscular atrophy
Y Takeuchi1, H Komatsu, S Matsuo
1Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan.
Neuroreport
|April 14, 1994
Abstract:
Analyses of tryptophan and tyrosine metabolites in cerebrospinal fluid were performed to examine an abnormality of the monoamine neurone system in severe infantile spinal muscular atrophy (SMA type I). The levels of 5-hydroxyindoleacetic acid and homovanillic acid were significantly lower than those in controls. Decreases in the concentration of 5-hydroxyindoleacetic acid and kynurenine seemed to be related to the severity of SMA type I. These results suggest that the monoamine neurone system may play a role in the pathophysiology of SMA type I.