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Circulating D dimer in inflammatory bowel disease

L Biancone1, F Scopinaro, M Maletta

  • 1Divisione Medicina Nucleare, Università La Sapienza, Roma, Italy.

The Italian Journal of Gastroenterology
|April 1, 1994
PubMed
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Elevated D dimer levels, a marker of fibrin degradation, are present in patients with ulcerative colitis. This finding suggests increased thrombogenesis in inflammatory bowel disease, particularly in ulcerative colitis with an acute phase response.

Area of Science:

  • Gastroenterology
  • Hematology
  • Clinical Chemistry

Background:

  • Activated thrombogenesis is a known complication in inflammatory bowel disease (IBD).
  • Fibrin degradation products, such as D dimer, are indicators of thrombotic activity.

Purpose of the Study:

  • To investigate whether D dimer levels are elevated in patients diagnosed with IBD.
  • To assess the correlation between D dimer levels and inflammatory markers in ulcerative colitis.

Main Methods:

  • Plasma D dimer levels were quantified using a sandwich ELISA.
  • Study included patients with Crohn's disease, ulcerative colitis, gastrointestinal disease controls, hospital controls, and healthy subjects.
  • Statistical analysis was performed to compare D dimer levels across groups and correlate them with clinical parameters.

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Main Results:

  • Significantly higher D dimer levels were observed in ulcerative colitis patients compared to healthy subjects, Crohn's disease patients, and GI disease controls.
  • In ulcerative colitis, plasma D dimer showed a strong correlation with inflammatory markers like C-reactive protein and seromucoids.
  • Circulating D dimer levels demonstrated an age-related trend across all study groups.

Conclusions:

  • Fibrin degradation, indicated by elevated plasma D dimer, is present in ulcerative colitis patients.
  • The findings suggest an association between D dimer levels, thrombogenesis, and the acute phase response in ulcerative colitis.
  • D dimer may serve as a potential biomarker for thrombotic activity in IBD.