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Cerebral vasocapacitance in human aging

R L Levine1, J M Hanson, R J Nickles

  • 1Department of Neurology/127, William S. Middleton Memorial Veterans Hospital, Madison, WI 53705.

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
|July 1, 1994
PubMed
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Increasing age is linked to reduced cerebral blood flow in normal individuals, but not significantly to diminished cerebral reserve percentage. In patients, age showed a trend towards decreasing cerebral reserve.

Area of Science:

  • Neurology
  • Vascular Biology
  • Medical Imaging

Background:

  • Age is a known factor influencing cerebrovascular function.
  • Understanding age-related changes in cerebral blood flow and reserve is crucial for assessing neurological health.

Purpose of the Study:

  • To investigate the relationship between age and cerebral blood flow (CBF).
  • To examine the association between age and cerebral vasocapacitance or cerebral reserve percentage.
  • To compare these relationships in normal subjects and patients with transient ischemic attacks (TIAs).

Main Methods:

  • Positron emission tomography (PET) with fluorine-18-fluoromethane was used.
  • 36 normal subjects and 36 patients with TIAs (asymptomatic carotid arteries) were studied.
  • Cerebral blood flow and cerebral reserve percentage were calculated for middle cerebral artery territories.

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Main Results:

  • In normal subjects, increasing age significantly correlated with decreasing CBF (37% decline over 60 years).
  • No significant age-related decrease in cerebral reserve percentage was found in normal subjects.
  • In patients, a trend suggested that declining cerebral reserve percentage approached significance with increasing age.

Conclusions:

  • Cerebral blood flow significantly decreases with age in healthy individuals.
  • Cerebral reserve percentage shows less of a direct age-related decline in normal subjects.
  • Age may be a more significant factor for reduced cerebral reserve in patients with cerebrovascular risk.