Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Laparoscopic live-donor nephrectomy

I S Gill1, J M Carbone, R V Clayman

  • 1Division of Urology, University of Kentucky Albert Chandler Medical Center, Lexington.

Journal of Endourology
|April 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact of face coverings on audio-visual contributions to communication with conversational speech.

Cognitive research: principles and implications·2024
Same author

Reply by Authors.

The Journal of urology·2020
Same author

Reply by Authors.

The Journal of urology·2020
Same author

Association between Smoking Exposure, Neoadjuvant Chemotherapy Response and Survival Outcomes following Radical Cystectomy: Systematic Review and Meta-Analysis.

The Journal of urology·2020
Same author

Live surgery: highly educational or harmful?

World journal of urology·2017
Same author

The design of and chronic tissue response to a composite nerve electrode with patterned stiffness.

Journal of neural engineering·2017

This study evaluated if a kidney could be safely removed using minimally invasive laparoscopic techniques for transplantation. Researchers compared laparoscopic removal to traditional open surgery in a pig model. Results showed that both methods yielded similar kidney function and anatomical integrity. The findings suggest that laparoscopic donor surgery is a viable and safe option for organ harvesting.

Area of Science:

  • Transplantation surgery research within laparoscopic nephrectomy medicine
  • Veterinary surgical science and experimental physiology

Background:

No prior work had resolved whether a healthy kidney could be harvested for transplantation using minimally invasive techniques. Surgeons previously utilized laparoscopic approaches primarily for removing diseased organs with ablative intent. That uncertainty drove the need to assess the feasibility of retrieving intact, functional kidneys. Prior research has shown that open surgery remains the standard for donor organ procurement. This gap motivated an investigation into whether laparoscopic methods could maintain necessary anatomical structures. Researchers needed to determine if vascular length and tissue health remained comparable to traditional open procedures. Previous studies focused on oncological outcomes rather than the specific requirements for successful organ transplantation. This investigation addresses the critical requirement for preserving physiological integrity during minimally invasive retrieval.

Purpose Of The Study:

The aim of this study was to determine if a physiologically and anatomically intact kidney could be harvested laparoscopically for transplantation. Researchers sought to evaluate the feasibility of this minimally invasive technique compared to traditional open surgery. The investigation addressed the challenge of maintaining vascular length and organ health during retrieval. This problem motivated the team to test the procedure in a controlled porcine model. They specifically examined whether the laparoscopic approach could provide a viable donor organ. The study sought to confirm that the technique does not cause intraoperative vascular damage. Furthermore, the researchers intended to compare post-transplant renal function between the two surgical methods. This effort aimed to provide evidence supporting the safety and reproducibility of laparoscopic organ harvesting.

Keywords:
minimally invasive surgeryrenal transplantationporcine modelsurgical outcomes

Frequently Asked Questions

The researchers propose that the laparoscopic approach is safe and reproducible, as evidenced by the lack of vascular injuries or ureteral complications. This contrasts with the open surgery control group, which also showed no such adverse events.

The study utilized in situ hypothermic perfusion to protect the organ during the laparoscopic retrieval process. This technique is distinct from the standard open surgery approach, which does not require this specific cooling intervention for the solitary kidney.

The authors state that the length of the renal artery and vein is necessary for successful transplantation. They measured these vessels to ensure the laparoscopic technique provided sufficient length compared to the open surgery method.

Related Experiment Videos

Main Methods:

Review approach involved a controlled experiment using fifteen pigs to compare two distinct surgical techniques. The investigation divided subjects into a study cohort and an open surgery control group. Surgeons performed a right nephrectomy on all animals three weeks before the primary procedure. The study group underwent laparoscopic retrieval of the remaining solitary kidney. The control group received traditional open surgery for the same organ removal. Investigators applied in situ hypothermic perfusion to all kidneys harvested via the laparoscopic method. The team measured the length of the renal artery and vein for both groups. Finally, the researchers monitored serum creatinine levels and performed histopathologic tissue analysis at specific intervals.

Main Results:

Key findings from the literature demonstrate that laparoscopic retrieval yields renal vascular lengths comparable to open surgery. The study group achieved a mean renal artery length of 3.1 cm and vein length of 3.4 cm. These values showed no significant difference from the control group, which measured 2.5 cm and 3.8 cm respectively. No intraoperative vascular injuries or postoperative ureteral complications occurred in either cohort. Histopathologic examination confirmed that tissue health remained consistent between the two surgical approaches. Serum creatinine levels at seven days were 2.1 mg/dL for the study group and 1.7 mg/dL for the control group. At thirty days, the study group recorded 1.6 mg/dL compared to 1.4 mg/dL in the control group. Statistical analysis confirmed these differences were not significant, with a p-value of 0.4.

Conclusions:

The authors propose that laparoscopic live-donor nephrectomy is both safe and reproducible within the porcine model. Synthesis and implications suggest that this minimally invasive approach yields outcomes comparable to traditional open surgery. Researchers observed no significant differences in vascular dimensions between the two surgical techniques. Furthermore, the study indicates that renal histopathology remains consistent across both experimental groups. Data regarding serum creatinine levels support the conclusion that post-transplant function is preserved. These findings imply that the laparoscopic method does not compromise the viability of the harvested organ. The evidence confirms that the procedure maintains the necessary anatomical integrity for successful transplantation. This work provides a foundation for considering laparoscopic retrieval as a viable alternative in clinical practice.

The researchers used serum creatinine levels as a quantitative data type to assess post-transplant renal function. They compared these values at 7 and 30 days, finding no significant difference between the laparoscopic and open surgery cohorts.

Histopathologic examination served as the measurement for assessing tissue health immediately after surgery and one month later. This analysis revealed similar findings between the laparoscopic and open surgery groups, indicating no structural damage occurred.

The researchers propose that their findings support the potential for clinical application of this minimally invasive technique. They suggest that laparoscopic harvesting could become a standard practice for organ donation, provided further validation occurs.