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Neuropsychological dysfunction in asthmatic children
1Department of Pediatrics, University of New Mexico, School of Medicine, Albuquerque 87131-5311.
Insights
Pediatric asthma generally does not cause uniform neuropsychological deficits. Asthma medications may have temporary, specific effects on attention and memory, warranting further study in children.
Area of Science:
- Neuropsychology
- Pediatric Medicine
- Pharmacology
Background:
- Pediatric asthma is frequently associated with concerns about neuropsychological functioning.
- Methodological challenges, including objective asthma measurement, complicate research.
- Existing evidence does not strongly support asthma as a sole cause of uniform cognitive deficits.
Purpose of the Study:
- To review neuropsychological dysfunction in pediatric asthma.
- To examine the impact of asthma medications on cognitive function.
- To discuss implications for pediatric neuropsychologists.
Main Methods:
- Literature review of studies on pediatric asthma and neuropsychological outcomes.
- Analysis of research on adverse effects of asthma medications.
- Consideration of confounding variables like socioeconomic status.
Main Results:
- Asthma alone is unlikely to cause homogeneous neuropsychological compromise.
- Asthma medications can have medication-specific effects on neuropsychological functions like attention and memory.
- Acute medication effects appear reversible, but long-term impacts on the developing nervous system are unknown.
Conclusions:
- The link between asthma and neuropsychological dysfunction is complex and influenced by medication.
- Poorly controlled asthma may be associated with learning difficulties.
- Further research is needed on long-term effects of asthma medications in children.
Abstract:
Neuropsychological dysfunction associated with pediatric asthma is reviewed. Significant methodological confounds associated with clinical research, including problems with the objective measure of asthma, are prevalent in many studies. Most evidence does not support the belief that asthma alone results in homogeneous neuropsychological compromise. Studies of adverse reactions to asthma medications indicate medication-specific effects including slight improvements in some aspects of neuropsychological functioning, such as attention, and deficiencies in other aspects of neuropsychological functioning, such as memory. The acute neuropsychological effects of various medication regimens appears to be reversible with cessation of the asthma medication under suspicion, although no data yet exist regarding the long-term effects of therapeutic dosages of asthma medications upon a developing nervous system. The hypothetical effects of asthma on school performance have been related to non-neuropsychological variables such as a child's socioeconomic status, though there is also evidence suggesting that poorly controlled asthma is related to learning problems. Implications for pediatric neuropsychologists are discussed.
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