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Kidney transplantation in children

S Sager1, R B Ettenger

  • 1Department of Pediatrics, UCLA School of Medicine.

Seminars in Pediatric Surgery
|November 1, 1993
PubMed
Summary

Pediatric kidney transplant success has risen significantly, with 1-year graft survival nearing 90%. Key factors include improved matching, immunosuppression, and rejection management, though disease recurrence remains a challenge.

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Area of Science:

  • Pediatric Nephrology
  • Transplantation Immunology

Background:

  • Pediatric kidney transplantation outcomes have improved over the last decade.
  • Histocompatibility testing, immunosuppressive management, and rejection protocols have advanced significantly.

Purpose of the Study:

  • To summarize the current state of pediatric kidney transplantation.
  • To highlight key factors influencing graft survival and complications.

Main Methods:

  • Review of recent advancements in pediatric kidney transplant care.
  • Analysis of factors affecting graft survival and post-transplant complications.

Main Results:

  • 1-year graft survival rates now exceed 90%.
  • Optimal recipient and donor age is over six years.
  • Recurrence of primary disease causes approximately 5% of graft loss.

Conclusions:

  • Sequential immunosuppressive protocols, including corticosteroids, azathioprine, and cyclosporin A, are effective in children.
  • Common post-transplantation complications include rejection, infection, hypertension, growth retardation, and noncompliance.

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