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Enhancement of gastric mucosal blood flow with sulglycotide
M Guslandi1, M Sorghi, A Tittobello
1Gastroenterology Unit, San Raffael Hospital, University of Milan, Italy.
Clinical Therapeutics
|March 1, 1994
Abstract:
Twelve patients with dyspepsia whose gastric abnormalities ranged from diffuse reddening of the mucosa to multiple erosions were treated for 4 weeks with oral sulglycotide, a sulphated glycopeptide with known gastroprotective and ulcer-healing properties. Before and after treatment, gastric mucosal blood flow was assessed by means of laser Doppler flowmetry. A significant (P < 0.01) increase in mucosal perfusion was observed after sulglycotide treatment, suggesting that enhancement of mucosal blood flow may contribute to the therapeutic properties of the drug.