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Related Experiment Videos

The transplanted human kidney does not achieve functional reinnervation

J M Hansen1, U Abildgaard, N Fogh-Andersen

  • 1Department of Nephrology, Herlev Hospital, University of Copenhagen, Denmark.

Clinical Science (London, England : 1979)
|July 1, 1994
PubMed
Summary

Transplanted kidneys show abnormal responses to noradrenaline and lower body negative pressure, suggesting they remain functionally denervated despite partial reinnervation. This impacts renal function and sodium excretion.

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Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Physiology

Background:

  • Histological studies indicate partial reinnervation of human transplanted kidneys.
  • The functional significance of this reinnervation remains unclear.
  • Investigating autonomic nervous system function in transplanted kidneys is crucial.

Purpose of the Study:

  • To assess the functional significance of reinnervation in transplanted kidneys.
  • To evaluate the response of transplanted kidneys to autonomic stimuli.
  • To compare renal haemodynamics and tubular function in short-term and long-term transplant recipients versus controls.

Main Methods:

  • Clearance studies were conducted in 25 renal transplant recipients (short-term and long-term) and 10 normal subjects.

Related Experiment Videos

  • Subjects underwent noradrenaline infusion and lower body negative pressure challenges.
  • Renal haemodynamics, sodium excretion, and tubular function (lithium clearance) were measured.

    • Main Results:

    • Transplanted kidneys exhibited supersensitivity to noradrenaline, with greater decreases in renal plasma flow, glomerular filtration rate, and sodium clearance compared to controls.
    • Lower body negative pressure significantly depressed glomerular filtration rate only in controls.
    • Transplanted kidneys showed a less pronounced response to lower body negative pressure, indicating inadequate autonomic function.

    Conclusions:

    • Human transplanted kidneys demonstrate functional denervation.
    • Supersensitivity to noradrenaline and an inadequate response to lower body negative pressure are present in transplanted kidneys.
    • These findings suggest that autonomic nervous system control of transplanted kidneys is significantly impaired.