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Updated: Aug 16, 2026

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
09:44

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation

Published on: September 11, 2012

Meconium ileus

M M Ziegler1

  • 1Division of Pediatric Surgery, Children's Hospital Medical Center, University of Cincinnati College of Medicine, Ohio.

Current Problems in Surgery
|September 1, 1994
PubMed

Insights

Meconium ileus, often caused by cystic fibrosis, is a bowel obstruction treatable by surgery or non-surgical methods. Post-treatment care focuses on nutrition and lung health for cystic fibrosis patients.

Area of Science:

  • Pediatric Gastroenterology
  • Pulmonology
  • Medical Genetics

Background:

  • Meconium ileus is a significant intestinal obstruction in newborns.
  • It is frequently associated with cystic fibrosis, an autosomal recessive genetic disorder.
  • Both surgical and non-surgical interventions can resolve meconium ileus.

Purpose of the Study:

  • To outline the clinical presentation and management of meconium ileus.
  • To emphasize the link between meconium ileus and cystic fibrosis.
  • To discuss current and future therapeutic strategies for cystic fibrosis.

Main Methods:

  • Review of clinical manifestations and treatment outcomes for meconium ileus.
  • Discussion of diagnostic criteria for cystic fibrosis.
  • Overview of management principles for intestinal and pulmonary manifestations of cystic fibrosis.

Main Results:

  • Nonoperative and operative therapies are effective for meconium ileus relief.
  • Successful nonoperative treatment was historically linked to better outcomes.
  • Management involves enzyme replacement for intestinal issues and respiratory care for lung disease.

Conclusions:

  • Meconium ileus necessitates prompt diagnosis and treatment.
  • Cystic fibrosis management requires a multidisciplinary approach addressing both gastrointestinal and pulmonary systems.
  • Emerging therapies offer hope for improved long-term outcomes in cystic fibrosis patients.

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